Identifying the subproteome of kinetically stable proteins via diagonal 2D SDS/PAGE
نویسندگان
چکیده
منابع مشابه
Identifying the subproteome of kinetically stable proteins via diagonal 2D SDS/PAGE.
Most proteins are in equilibrium with partially and globally unfolded conformations. In contrast, kinetically stable proteins (KSPs) are trapped by an energy barrier in a specific state, unable to transiently sample other conformations. Among many potential roles, it appears that kinetic stability (KS) is a feature used by nature to allow proteins to maintain activity under harsh conditions and...
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Inspired by work of McMullen, we show that any orbit of the diagonal group in the space of lattices accumulates on the set of stable lattices. As consequences, we settle a conjecture of Ramharter concerning the asymptotic behavior of the Mordell constant, and reduce Minkowski’s conjecture on products of linear forms to a geometric question, yielding two new proofs of the conjecture in dimension...
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Inspired by work of McMullen, we show that any orbit of the diagonal group in the space of lattices accumulates on the set of stable lattices. As consequences, we settle a conjecture of Ramharter concerning the asymptotic behavior of the Mordell constant, and reduce Minkowski’s conjecture on products of linear forms to a geometric question, yielding two new proofs of the conjecture in dimension...
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ژورنال
عنوان ژورنال: Proceedings of the National Academy of Sciences
سال: 2007
ISSN: 0027-8424,1091-6490
DOI: 10.1073/pnas.0705417104